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The aim of the current study was to examine the dual role of personality and psychopathology in predicting substance use among first-year students. 103 first-semester undergraduate students were recruited via the university subject pool. Participants completed personality questionnaires, structured clinical interviews, followed by the completion of diary entries each week reporting on substance use throughout their first semester. Results indicated that a diagnosis of an affective (mood/anxiety/stress) disorder was the most significant pr