https://www.selleckchem.com/pr....oducts/CP-690550.htm
Our data provide mechanistic insight into this phenotype and establish a mechanism for how HPF protects ribosomes during quiescence.ImportanceThe formation of ribosome dimers during periods of dormancy is widespread among bacteria. Dimerization is typically mediated by a single protein, Hibernation Promoting Factor (HPF). Bacteria lacking HPF exhibit strong defects in viability and pathogenesis and in some species, extreme loss of ribosomal RNA. The mechanistic basis of these phenotypes has not been determined. Here, we report that HP
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