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Accurate detection of liver steatosis is important for liver disease management. Ultrasound attenuation coefficient estimation (ACE) has great potential in quantifying liver fat content. The commonly used ACE methods (e.g., spectral shift methods, reference phantom methods) assume linear tissue response to ultrasound and were developed in fundamental imaging. However, fundamental imaging may be vulnerable to reverberation clutters introduced by the body wall. The clutters superimposed on liver echoes may bias the attenuation estimation.
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