https://www.selleckchem.com/MEK.html
There was also a marked increase in expression, storage, and release of the von Willebrand factor (VWF) and decreased storage and release of angiopoietin-2 in TM -/- cells. In a flow chamber assay, isolated platelets adhered to TM -/- cells, forming characteristic VWF-platelet strings. Increased VWF levels and inflammatory foci were also observed in the lungs of tamoxifen-treated ERcre-TMf/f mice. Reexpression of the TM construct in TM -/- cells, but not treatment with soluble TM, normalized the cellular phenotype. Based on these results, we postula
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