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How Does ADHD Medication Work? When one neuron sends a signal to another, it uses neurotransmitters or chemicals. These chemicals must travel through a small gap that is called a synapse. Some ADHD medications can make the transmission of these messages more efficient. They may aid neurons in releasing more neurotransmitters, or slow down the process of reuptake (called reuptake inhibitors). Doctors put patients suffering from ADHD with a small dose of medication and t