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Medication For ADHD - What Are the Side Effects? Many people who suffer from ADHD have their symptoms improved through medication. Each person's reaction to drugs is different, and the side effects can be problematic. Methylphenidate is a stimulant. It increases the levels of a chemical in the brain that regulates behavior and attention. Stimulant drugs Stimulants enhance concentration and attention in 70 to the 80% of children and adults who use them. They work by altering neurotransmitters such as norepinephrine and dopamine in the brain