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ADHD Medications - Stimulant Or Non Stimulant? Stimulant drugs are the first-choice ADHD medications, they with the most research-based backing behind them, and are fast-acting. However, they're not suitable for everyone. These medications boost signaling between nerves and regions in the brain, thereby reducing symptoms of ADHD. They can also have adverse effects such as the loss of appetite or changes in blood pressure or heart rate. Stimulants The most common medication used to treat ADHD is stimulants. They are known for improving the qua