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How Does ADHD Medication Work? When a neuron transmits a signal to another, it uses neurotransmitters, which are chemicals that act as. They need to cross a tiny gap called the synapse. can increase the efficiency of these messages. They may aid neurons in releasing more neurotransmitters or slow the process of reuptake (called Reuptake inhibitors). Doctors begin ADHD patients on a low dosage and monitor their reaction. They adjust the dosage gradually to find the "sweet spot," the low
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