Chemical Structure : Adavosertib
CAS No.: 955365-80-7
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Adavosertib(AZD-1775;MK-1775)
Catalog No.: URK-V1391聽聽Only Used For Lab.
A potent and selective small-molecule inhibitor of Wee1 kinase with IC50 of 5.2 nM.
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Biological Activity
A potent and selective small-molecule inhibitor of Wee1 kinase with IC50 of 5.2 nM; exhibits ATP-competitive and highly selective against other serine/threonine or tyrosine kinases; inhibits phosphorylation of CDC2 at Tyr15 in cells; potentiates tumor growth inhibition in vivo.
Lung Cancer
Phase 2 Clinical
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Physicochemical Properties
M.Wt500.595
FormulaC27H32N8O2
CAS No.955365-80-7
StorageSolide Powder
-20 掳C 3years;
4掳C 2yearsIn Solvent
-80掳C 6 Months
-20掳C 1 Months
Solubility10 mM in DMSO
Chemical Name3H-Pyrazolo[3,4-d]pyrimidin-3-one, 1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-
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References
1. Hirai H, et al. Mol Cancer Ther. 2009 Nov;8(11):2992-3000.
2. Hirai H, et al. Cancer Biol Ther. 2010 Apr 1;9(7):514-22.
3. Bridges KA, et al. Clin Cancer Res. 2011 Sep 1;17(17):5638-48.
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URK-V1199_COA
URK-V1199_SDS
URK-V1199_SDS
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聽Small molecules Cell Cycle/DNA Damage
website:http://www.ureiko-chem.com/inh....ibitors-agonists/cel