https://www.selleckchem.com/pr....oducts/Dihydroartemi
Docking studies were undertaken to gain insight into the possible binding mode of these compounds with the voltage-gated sodium channel 1.7. The moderate toxicity of the leading compound 12 (50% lethal dose (LD5 value was more than 600 mg/kg in vivo) and cytotoxicity to cancer cell lines in vitro encouraged the further design of therapeutically relevant analogues based on this novel type of lappaconitine-pyrimidine hybrids.Serum alkaline phosphatase (ALP), a well-known marker of hepatobiliary and bone disorders, has re
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