https://www.selleckchem.com/pr....oducts/VX-680(MK-045
The addition of intrathecal morphine (ITM) to neuraxial anesthesia during total knee arthroplasty (TKA) to achieve postoperative analgesia can elicit opioid-related side effects. The other methods of pain alleviation and side effect reduction, including multimodal analgesia, are challenging. This study aimed to determine the efficacy of various ITM dosages for primary unilateral TKA with periarticular injection (PI). This randomized double-blind controlled trial was conducted at Vajira Hospital between April 2018 and March 2019.
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