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Given the frequency of flares, the impaired quality of life during the post-flare period, and safety/tolerability issues, it is clear that current treatment options are not sufficient. Long-term studies utilizing the European consensus statement with subclassifiers are required to supplement our current understanding of the burden of GPP.Although actively disputed and questioned, it has been proposed that chronic exposure to inorganic fluoride (F-) is toxic for brain. The major question for this review was whether an excessive F- intake
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