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Stratified analyses showed specific associations of with lcSSc, and an exclusive association of with dcSSc. Similarly, private associations were detected in and confirmed the previously reported association of with ACA-positive patients, as opposed to the and alleles associated with ATA presentation. This study confirms the contribution of HLA class II and reveals a novel association of HLA class I with SSc, suggesting novel pathways of disease pathogenesis. Furthermore, we describe specific HLA associations with SSc clinical and serol
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