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This method can be used in the standardization of raw materials, as well as in the analysis of medicinal products and dietary supplements that include C. erythraea. The established chromatographic method was successfully applied for the analysis of raw materials of C. erythraea with the quantitative content determination of swertiamarin in the analyzed samples. Safe and effective drugs are still lacking for many pain therapies. In recent years, growing interest has been devoted thus on herbal drugs as an option to identify new pain kill