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Particular tips are given for an evidence-based and clinically-useful explanation of SARS-CoV-2 spike-targeted serology to identify vulnerability to illness and potential subsequent unfavorable results. Decreased vaccine effectiveness among immunocompromised people is linked to correspondingly high rates of breakthrough attacks. Negative outcomes on SARS-CoV-2 antibody examinations tend to be associated with increased risk for subsequent disease. "Low-positive" outcomes on semiquantitative S
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