https://www.selleckchem.com/pr....oducts/Ispinesib-mes
Objective The expression and function of platinum transporters affect drug tissue concentration and therapeutic effects. We had previously characterized functional variant of platinum intake transporter SLC31A1 gene. We aimed to investigate the association of platinum efflux transporter gene ABCG2 polymorphism and combined ABCG2 and SLC31A1 polymorphisms with clinical outcomes of NSCLC patients receiving platinum-based chemotherapy. Methods We genotyped thirteen tagging and functional SNPs of ABCG2 in 1004 patients
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