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Pregnancy is characterized by increased appetitive drive beginning early in gestation, yet the central mechanisms underlying this adaptation are poorly understood in humans. To elucidate central mechanisms underlying appetite regulation in early pregnancy, we examine plasma and CSF leptin and AgRP as well as CSF POMC as surrogates for brain melanocortin activity. Plasma leptin, Ob-Re, AgRP, and CSF leptin, POMC, and AgRP were collected from pregnant women prior to cerclage placement (16.6±1.1wks; N=24), scheduled cesarean section (39.2±
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