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COVID-19 is the latest global pandemic caused by severe acute respiratory syndrome coronavirus -2 (SARS-CoV-2). There have been seven pathogenic Human Coronaviruses (HCoVs) which cause respiratory infections. Common cold coronaviruses HCoV-229E, HCoV-OC43, HCoV-NL63, HCoV-HKU1 are the four endemic HCoVs. SARS-CoV-1, MERS-CoV, SARS-CoV-2 are zoonotic emerging epidemic pathogens with significant morbidity, mortality and economic impact. The endemic HCoVs have been known to cause co-infections or can be co-detected with each other or with
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