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may have implications for surveillance and chemopreventive strategies targeting the epigenome. This was a pilot study to analyze the effects of tracheostomy on patient-ventilator asynchronies and respiratory system mechanics. Data were extracted from an ongoing prospective, real-world database that stores continuous output from ventilators and bedside monitors. Twenty adult subjects were on mechanical ventilation and were tracheostomized during an ICU stay 55% were admitted to the ICU for respiratory failure and 35% for neurologic cond