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ity of recurrence and at a high risk of poor outcomes. Our study provides insights into new personalized therapies on the basis of mutation status and multi-omics data.The catalytic hydrotreatment of sewage sludge, the wet solid byproducts from wastewater treatment plants, using supported Ir, Pt, Pd, Ru catalysts had been investigated with different solvent conditions. Reactions were carried out in a batch set-up at elevated temperatures (400 °C) using a hydrogen donor (formic acid (FA) in isopropanol (IPA) or hydrogen gas), with sewage sludge obtained from