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We found that metformin blunted PRT-induced muscle hypertrophic reaction. To know potential components fundamental the inhibitory aftereffect of metformin on PRT, we examined the muscle mass transcriptome in 23 metPRT and 24 plaPRT members. PRT somewhat increased phrase of genetics associated with extracellular matrix renovating paths, and downregulated RNA processing pathways in both groups, nevertheless, metformin attenuated the number of differentially expressed genetics within these paths compare

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