https://www.selleckchem.com/pr....oducts/ag-221-enasid
t combined expression of the HR gene BRCA1, the NHEJ gene PRKDC (DNA-PK), and PARP1 may predict survival and found that overexpression of 0 (n=101), 1-2 (n=287), or all 3 genes (n=26) had a negative impact on median survival (undefined vs. 57.8 vs. 14.8 months, p less then 0.0001). Here we demonstrated PARPi synergized with MEL, but resistance (which may be due to HR and NHEJ pathways) is not completely reversed by PARPi. In addition, we observed that a 3 gene analysis may be tested to identify patients resistant or sensitive
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