https://www.selleckchem.com/pr....oducts/glesatinib.ht
Bones do not normally have lymphatics. However, patients with generalized lymphatic anomaly (GLA) or Gorham-Stout disease (GSD) develop ectopic lymphatics in bone. Despite growing interest in the development of tissue-specific lymphatics, the cellular origin of bone lymphatic endothelial cells (bLECs) is not known and the development of bone lymphatics has not been fully characterized. Here we describe the development of bone lymphatics in mouse models of GLA and GSD. Through lineage tracing experiments, we show that bLECs arise from
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