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INTRODUCTION A comprehensive characterisation of the tumour microenvironment is lacking in neuroendocrine tumours (NETs), where programmed cell death-1 receptor-ligand (PD-1/PD-L1) inhibitors are undergoing efficacy testing. OBJECTIVE We investigated drivers of cancer-related immunosuppression across NETs of various sites and grade using multi-parameter immunohistochemistry and targeted transcriptomic profiling. METHODS Tissue microarrays (n=102) were stained for PD-L1 2, Indoleamine-deoxygenase-1 (IDO-1) and evaluated in relations
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