https://www.selleckchem.com/pr....oducts/pf-04691502.h
This order of sensitivity is reversed for FLT3i. Cytarabine induced apoptosis in the S-phase while all FLT3i induced apoptosis and cell cycle arrest at G1 phase. Simulations of candidate clinical regimens predict better cell kill upon adding quizartinib simultaneously with or immediately after CYT exposure. Overall survival was predicted to be significantly better with quizartinib 200mg administered every 48h vs every 24h in patients with FLT3 aberrations. Simultaneous administration of quizartinib and CYT every other day is a promi
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