https://www.selleckchem.com/pr....oducts/tecovirimat.h
Pulmonary hypertension (PH) is a common complication of left heart disease (LHD, group 2 PH) leading to right ventricular (RV) failure and death. Several loss-of-function (LOF) mutations in KCNK3 were identified in pulmonary arterial hypertension (PAH, group 1 PH). Additionally, we found that KCNK3 dysfunction is a hallmark of PAH at pulmonary vascular and RV levels. However, the role of KCNK3 in the pathobiology of PH due to LHD is unknown. We evaluated the role of KCNK3 on PH induced by ascending aortic constriction (AAC), in WT a
Like
Comment
Share
