https://www.selleckchem.com/pr....oducts/tofa-rmi14514
jagus crude alkaloid extract inhibited DENV infection. Among the purified AAs, cherylline inhibited efficiently both DENV (EC50=8.8 μM) and ZIKV replication (EC50=20.3 μM), but had no effect on HIV-1 infection. Time-of-drug-addition and -removal experiments identified a post-entry step as the one targeted by cherylline. Consistently, using subgenomic replicons and replication-defective genomes, we demonstrate that cherylline specifically hinders the viral RNA-synthesis step but not viral translation. In conclusion, AAs are an unde
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