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Key informant interviews (n = 13) revealed how LGBTQ+ Latinx organizations emerged after the shooting to mobilize for greater health equity and health programs that directly respond to populations who experience unique inequalities related to their intersecting LGBTQ+ and Latinx identities. Findings from this article show how attention to intersectionality can inform efforts to mitigate existing syndemics and prevent future syndemics. Such efforts are needed to adequately examine the social contexts in which sy