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ion ( = 0.0003) in CN but not in aMCI or AD. To our knowledge, this is the first study to show that it is possible to measure p-BEM with precision at UHF across the three groups. Moreover, the findings suggest that p-BEM may be compromised in aMCI even before an AD diagnosis, which in future studies should explore to examine whether this energy crisis contributes to some of the earliest neuropathophysiologic changes in AD. To our knowledge, this is the first study to show that it is possible to measure p-BEM in vivo with precision at UH

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