https://www.selleckchem.com/pr....oducts/bay-87-2243.h
Phosphorylation of kinases and specific substrates was measured at 20 and 60min. Kinome analysis of our data indicates that Mycoplasma DnaK promotes the dysregulation of the activity of specific kinases and their substrates, with a known involvement in carcinogenesis and cancer progression. Given the similarity in structure and amino acid composition of this protein with other bacterial DnaKs we provide a novel mechanism whereby components of the human microbiota and present in the tumor microenvironment are able to deregulate phosp
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