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These measurements were repeated after 6 months. The mean reduction in the horizontal defect depth was 1.86 ± 0.66 mm (70.75%) in site A and 1.71 ± 0.73 mm (74.25%) in site B. The mean improvement in the vertical defect fill was 1.64 ± 0.74 mm (55.8%) in site A and 1.43 ± 1.34 mm (64.86%) in site B was achieved. The use of combination therapy using either BA or DFDBA in conjunction with PRF appears to be effective in treating furcations. The use of combination therapy using either BA or DFDBA in conjunction with PRF appears to be effect