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A Correction to this paper has been published https//doi.org/10.1038/s41590-021-00932-2.A Correction to this paper has been published https//doi.org/10.1038/s41590-021-00929-x.Although the pathological significance of tumor-associated macrophage (TAM) heterogeneity is still poorly understood, TAM reprogramming is viewed as a promising anticancer therapy. Here we show that a distinct subset of TAMs (F4/80hiCD115hiC3aRhiCD88hi), endowed with high rates of heme catabolism by the stress-responsive enzyme heme oxygenase-1 (HO-1), plays a critical role in
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