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Additionally, we reveal that CDDO-Im binds covalently to Keap1 by developing permanent Michael adducts with eight various cysteines, and acyl adducts with lysine and many tyrosine residues. Modeling scientific studies suggest that the Tyr 85 adduct stabilizes the Keap1-Cul3 complex, thereby enhancing the effectiveness of CDDO-Im.Human tyrosinase (hsTYR) is the key enzyme ensuring the conversion of l-tyrosine to dopaquinone, thereby starting melanin synthesis, i.e., melanogenesis. Even thoug
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