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Here we propose that AIFM1 and Nde1 serve as conserved redox switches which measure metabolic problems from the mitochondrial surface and translate it into a binary life/death decision. This function is conserved among eukaryotic cells and evidently used to purge metabolically compromised cells from populations.In micro-organisms, cell-surface polysaccharides fulfill crucial physiological functions, including interactions aided by the environment and other cells as well
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