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How Does Medication For ADHD Work? Most people find that their symptoms improve when they take a medication. However, finding the right medication and dose is a process that requires time, patience and open communication with your GP or specialist. Treatments for ADHD work by adjusting the levels of certain chemical messengers in your brain. Stimulant medicines, like methylphenidate, help focus and decrease impulsivity and hyperactivity. Atomoxetine (Strattera) and guanfacine (Tenex, Intuniv) are non-stimulant medications that improve behavior reduce tics, and he