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242, P = 0.017). We further discovered that leptin level is positively correlated with WC (r = 0.504, P  0.0001) and the CASS value (r = 0.36, P  0.0001). Further mediation analysis shows that leptin level serves as mediators between higher WC and higher CASS. Our results highlighted the relationship among leptin, central obesity, and severity of CAN. As the leptin level serves as mediator between central obesity and severity of CAN, a longitudinal study is needed to confirm that control of WC can decrease leptin levels and can

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