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ADHD Stimulant Medication Stimulants help about 70 percent to 80% children and adults suffering from ADHD. They alleviate symptoms by boosting dopamine and norepinephrine levels. These medicines begin working within 30 to 45 minutes and last for 3 to 6 hours. They are available as liquid or chewable tablets. Your doctor might also prescribe nonstimulant medications to