https://www.selleckchem.com/pr....oducts/epacadostat-i
Importantly, treatment with an SHH inhibitor (RU-SKI 43) but not a NOTCH inhibitor (DAPT) reduced cell survival in NKX6-1-expressing cancer cells, indicating that an SHH inhibitor could be useful in treating LMS. Finally, using the TCGA dataset, we demonstrated that LMS patients with high expression of NKX6-1 and HHAT, an SHH pathway acyltransferase, had poorer survival outcomes compared to those without. Our findings indicate that NKX6-1 and HHAT play critical roles in the pathogenesis of LMS and could be promising diagn
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