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To review the effectiveness of health education interventions adapted for culturally and linguistically diverse (CALD) populations with a chronic illness. A systematic review and meta-analysis were conducted. Eligible studies were identified across six databases. Data were extracted and intervention effect was summarized using standardized mean difference. If there were insufficient data for meta-analysis, a descriptive summary was included. Modifying effects of intervention format, length, intensity, provider, self-management skills tau