https://bix01294inhibitor.com/....patch-seq-displays-y
HIF-1α was immunoprecipitated and afflicted by ubiquitination analysis via western blotting. The appearance of SPP1, VHL and HIF-1α had been analyzed by RT-qPCR and western blotting. SPP1 elevates Th17/Treg and M1/M2 ratio by controlling VHL appearance and ubiquitination-dependent HIF-1α degradation, hence exacerbating ARDS. Our study provides novel mechanistic ideas into ARDS pathogenesis and promising healing goals.SPP1 elevates Th17/Treg and M1/M2 ratio by controlling VHL appearance
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