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er and redistribution of AQP4 were identified which may contribute to epileptogenesis. This constitutes the largest study in the published literature evaluating a role of vascular permeability and angiogenesis in human hippocampal sclerosis. Our aim was to identify patients with SCN1A-related epilepsy with a phenotype of pure focal epilepsy. We conducted a retrospective study and a systematic review in Pubmed to identify patients with focal epilepsy associated with SCN1A pathogenic variants. We found three patients among 1,191 in our r
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