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PR = 3.10, 95% CI 1.07-8.97) were all found to be significantly associated with having ever had an opioid overdose. We demonstrate factors associated with opioid overdose among women who use drugs in Tanzania that may not be addressed with injection-focused harm reduction efforts. Our findings suggest the need for overdose surveillance efforts and further work to characterize overdose risks in this context in order to design relevant, targeted interventions to prevent opioid overdose in sub-Saharan Africa. We demonstrate factors asso