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Does ADHD Medication Work? When a person is prescribed ADHD medication, they fret about how long the treatment will last and whether it will work. Here are some simple answers. Stimulants modify brain chemicals that relay messages about attention and activity. Norepinephrine, dopamine and other brain chemicals are also included. They are the first-line treatment for adults suffering from ADHD. 1. Stimulants Stimulants are the most frequently used medications to manage ADHD. They alter the activity of neurotransmitters