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subtilis. This is of great interest as these proteins are highly conserved, and often involved in altering gene expression in response to changes in environmental conditions. For many of the bacteria we will examine in this review, the ability to sense environmental changes and alter gene expression accordingly is critical for survival and colonization of susceptible hosts.Tuberculosis (T, caused by Mycobacterium tuberculosis (Mtb) remains a major public health problem worldwide due in part to the lack of an effec