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The Most Effective ADHD Medication For Adults The majority of the drugs used to treat ADHD are divided into two groups: stimulants and nonstimulants. Stimulants like methylphenidate (Provigil) and amphetamines act by enhancing the activity of parts of the brain that control the behavior and attention. Non-stimulants, such as guanfacine atomoxetine, and clonidine, work slower than stimulants, however they can help improve concentrat
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