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How Does ADHD Medication Work? ADHD is treated with stimulants. They regulate the levels of neurotransmitters (two brain chemicals) that transmit messages between neurons in order to improve attention and reduce excessive hyperactivity. However, as many as 20 percent of people do not respond to the most frequently prescribed stimulants, methylphenidate or amphetamine. This could be due to the chemistry of the body of the individual or other medications they are taking. What are the sig
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