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hors. The Journal of Physiology © 2020 The Physiological Society.The co-evolving tumour cells and the systemic immune environment are mutually dysregulated. Tumours affect the immune response in a complex manner. For example, while lymphocytes are mobilized in response to tumours, their function is impaired by tumour progression. This study aimed to explore how the baseline and dynamic renal cell carcinoma (RCC) tumour burdens affect the T cell repertoire, and whether the baseline T cell receptor β chain (TCR diversity predicts prognos
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