https://www.selleckchem.com/pr....oducts/cp21r7-cp21.h
[Figure see text]. Restricted mean survival time methods compare the areas under the Kaplan-Meier curves up to a time τ for the control and experimental treatments. Extraordinary claims have been made about the benefits (in terms of dramatically smaller required sample sizes) when using restricted mean survival time methods as compared to proportional hazards methods for analyzing noninferiority trials, even when the true survival distributions satisfy proportional hazardss. Through some limited simulations and asymptotic power calc
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