https://www.selleckchem.com/pr....oducts/s64315-mik665
Interestingly, only female ECMS mice at adulthood maintained juvenile-like OD plasticity as well as high NR2B expressions. Artificial increase in estradiol level in ECMS males via estradiol supplementary diminished this sex difference. Lastly, OD plasticity was abolished in adult ECMS females either performed with the bilateral ovariectomy in prepuberty, or directly infused with NR2B antagonist Ro 25-6981 into the visual cortex. Overall, our study demonstrates that early adverse experiences have a lasting effect on visual developm
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