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The mean ME and MAE were 1.4, 29.6, 5.4 Hounsfield units (HU) and 77.2, 94.2, 41.8 HU for HN, thoracic and pelvic region, respectively. Dice similarity coefficients varied between 66.7±8.3% (seminal vesicles) and 94.9±2.0% (lungs). Maximum mean surface distances were 6.3mm (heart), followed by 3.5mm (brainstem). The mean dosimetric differences of the target volumes did not exceed 1.7%. Mean 3D gamma pass rates greater than 97.8% were achieved in all cases. The presented method generates sCT images with a quality close to pCT and y